Plant Transcription Factor Database
Previous version: v3.0
Pyrus bretschneideri
E2F/DP Family
Species TF ID Description
Pbr010366.1E2F/DP family protein
Pbr010427.1E2F/DP family protein
Pbr011800.1E2F/DP family protein
Pbr011903.3E2F/DP family protein
Pbr013450.2E2F/DP family protein
Pbr015398.1E2F/DP family protein
Pbr029524.1E2F/DP family protein
Pbr039974.1E2F/DP family protein
Pbr042159.1E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710